2017-12-01

Current practice recommends adjusting renally eliminated drugs according to the Cockcroft–Gault equation. There are no data on the utility of the Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD‐EPI) equations in ganciclovir dosing.

MDRD GFR, CKD-EPI GFR, Cockcroft & Gault applicability in CKD versus AKI and CRRT. – Estimating extra-cellular fluid volume e.g. eGFR USING CKD- EPI, MDRD AND COCKCROFT- GAULT AND GLYCAEMIC. CONTROL AMONG TYPE 2 DIABETICS IN AN OUT- PATIENT CLINIC IN. A number of recognised and well-validated formulae have been used for this purpose including the MDRD and CKD-EPI equations. “Normal” GFR is usually > 90 27 Sep 2015 Calculate estimated GFR using the CKD-EPI formula. rate (GFR) from serum creatinine and other readily available clinical parameters, especially at The CKD-EPI equation performed better than the MDRD (Modification o 7 Nov 2008 Estimating equations like the MDRD equation play an important role in CKD diagnosis and treatment.

The CKD-EPI equation gave somewhat higher eGFR estimates than the MDRD formula (95.2 mL/min/1.73 m 2 and 90.4 mL/min/1.73 m 2 by CKD-EPI and MDRD creatinine equations, respectively; p < 0.001), resulting in smaller but non-significant numbers of patients with eGFR <90 mL/min/1.73 m 2 (27.4% vs. 34%). Aims. To analyze the performance of Modification of Diet in Renal Disease (MDRD), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), Cockcroft-Gault (CG), and CG calculated with ideal bodyweight (CG-IBW) equations to estimate glomerular filtration rate (eGFR) based on serum creatinine in a large diabetic population. By comparison the mean differences for predictive equations were: CKD-EPI cystatin C 10.2 (43.7,-23.4), CKD creatinine-cystatin C 6.5 (29.3,-16.3) and MDRD 3.2 (18.3,-11.9).

Summary of the MDRD Study and CKD-EPI Estimating Equations The table below summarizes GFR estimating equations developed by the Modification of Diet in Renal Disease (MDRD) Study Group and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI). The latest versions of these equations are based on

Ele est plus correcte pour les valeurs de clairance de la créatinine dépassant les 60 ml/min/1,73 m 2. Références. A New Equation to Estimate Glomerular Filtration Rate.

ease Epidemiology (CKD-EPI) and Modification of Diet in Renal Dis- ease (MDRD) equations to estimate glomerular filtration rate in a large.

Cystatin C. eGFR, bäst vid. GFR 20-90. Inulinclearance Gold standard. Forskning. Jämförelse av CKD-EPI och MDRD ekvationsformler för estimerad glomerulär filtrationshastighet. Kandidat-uppsats, Luleå tekniska universitet/Institutionen för ekvationen tillsammans med MDRD och CKD-EPI ekvationerna. LM reviderad ekvationen som då är baserad på skånska patienter ger en CKD-epi formeln.

CKD-EPI equation to estimate glomerular filtration rate in kidney transplant recipients. Transplantation.
Model 1930

The Modification of Diet in Renal Disease (MDRD) Study equations and, more recently, the Chronic Kidney Disease Epidemiology Collaboration (CKD‐EPI) equation, provide an estimated glomerular filtration rate (GFR) and are widely used for staging chronic kidney disease 7 - 9. As shown in the figure below, the CKD-EPI equation and the MDRD Study equation were equally accurate in a subgroup with estimated GFR (eGFR) less than 60 mL/min/1.73 m 2. However, the CKD-EPI equation was more accurate in a subgroup with eGFR between 60 and 120 mL/min/1.73 m 2. CKD 3 or higher stages. Use of the CKD-EPI formula rather than the MDRD formula reduced the proportion of younger patients with CKD stage 3 or worse but increased the proportion of older patients with CKD stage 3 or worse.

Summary of the MDRD Study and CKD-EPI Estimating Equations The table below summarizes GFR estimating equations developed by the Modification of Diet in Renal Disease (MDRD) Study Group and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI). The latest versions of these equations are based on Both MDRD and CKD-EPI were well-correlated with reference GFR (0.806 and 0.867 respectively) and statistically significant with p < 0.001.
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CKD 3 or higher stages. Use of the CKD-EPI formula rather than the MDRD formula reduced the proportion of younger patients with CKD stage 3 or worse but increased the proportion of older patients with CKD stage 3 or worse.

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Variabler LM-reviderad MDRD-IDMS CKD-EPI Bias (95 % KI) In the overall cohort, although MDRD had smaller bias than CKD-EPI (4.81 vs. 6.54), CKD-EPI was more precise (25.22 vs. 20.29) with higher accuracy within 30% of measured GFR (79.65 vs. 86.73%). The CKD-EPI equation appeared to be more precise and accurate than the MDRD equation in estimating GFR in our cohort of multi-ethnic populations in Malaysia. MDRD and CKD-EPI estimated most accurately in stages 1 (MDRD:57.7%, CKD-EPI:57.3%) and 2 (MDRD:80.2%, CKD-EPI:80.7%). In stages 3 to 5, highest accuracy was observed for the MDRD (stage 3:82.3%, stage 4:77.8%, stage 5:71.0%).

Inulinclearance Gold standard.